PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4098)
Related Products (4098)
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PROTAC Linkers Isoform Comparison
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(3R,4R)-3-Methyl-4-piperidinol
0 ImagesCat. No.: HY-W267161CAS No.: 373604-43-4
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[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid
![[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid](https://file.medchemexpress.com/product_pic/hy-140327.gif "Click to View [10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid Product Detail")
0 ImagesCat. No.: HY-140327CAS No.: 1446282-24-1
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Benzyl-PEG2-acid
0 ImagesCat. No.: HY-W096142CAS No.: 91555-65-6
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5-Hydroxypentanoic acid
0 ImagesCat. No.: HY-W041652CAS No.: 13392-69-3
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Amino-PEG10-OH
0 ImagesAmino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG10-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Boc-PEG1-PPG2-C2-azido
0 ImagesCat. No.: HY-138474Boc-PEG1-PPG2-C2-azido is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-PEG1-PPG2-C2-azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bis-methacrylate-PEG5
0 ImagesCat. No.: HY-W096161CAS No.: 13497-24-0
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Pip-alkyne-Ph-COOCH3
0 ImagesCat. No.: HY-130846CAS No.: 2308496-47-9
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Boc-aminocyclobutoxy-benzofuran-acid
0 ImagesCat. No.: HY-175582CAS No.: 2086300-68-5
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Br-PEG6-C2-acid
0 ImagesCat. No.: HY-138362CAS No.: 309916-91-4
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(S,R,S)-AHPC-amide-PEG5-C2-azide
0 ImagesCat. No.: HY-176536CAS No.: 2412055-42-4Synonyms: VH032-CO-(CH2)2-(O-CH2-CH2)5-azide
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Boc-piperazine-pyridine-COOH
0 ImagesCat. No.: HY-W086181CAS No.: 201809-22-5
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N-Me-N-bis(PEG4-acid)
0 ImagesCat. No.: HY-140579CAS No.: 2055014-77-0
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Carboxyrhodamine 110-PEG4-alkyne
0 ImagesCat. No.: HY-141089CAS No.: 2055103-66-5
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Azido-PEG10-azide
0 ImagesCat. No.: HY-132076CAS No.: 1421783-42-7Azido-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
